High levels of testosterone, bad news for the heart

According to a recent study, high levels of testosterone can dramatically increase the risk of heart failure and blood clots that cause a stroke

The researchers found that men with a genetic predisposition to high levels of testosterone have an almost eightfold increased risk of heart failure and twice the risk of thromboembolism (blood clots that block the veins or arteries that block the brain or lungs).

Although the trial of high levels of testosterone in men naturally focuses on implications for the elderly, taking testosterone supplements has increased your energy and sexual desire, according to experts.

Testosterone sales between 2000 and 2011, especially in the United States, 12 times in the world increased so the researchers in the Supporting Information.

“This study serves as a red stop sign, a warning that higher circulating testosterone can cause an increase in cardiovascular events that are associated with an increased risk of death,” Dr. Guy Mintz. He is Head of Cardiovascular Health and Lipidology at the Heart Hospital of North Sandra Atlas Bass Health in Manhasset, N.Y.

For the study, an international team of researchers led by C. Mary Schoo of the School of Public Health and Health Policy of the City University of New York, analyzed genetic variants that predict levels of testosterone, and then whether these valued variants appear to be of value To influence the person. Risk of blood clots, heart failure or heart attack.

The researchers found the genes of testosterone using data from 3225 men 50 to 75 years, who participated in a worldwide study of prostate cancer screening. The researchers reviewed the levels of testosterone in men and then saw whether those with the highest levels had a common genetic variant.

Then, researchers compared these genes with medical data from more than 392,000 British men and women to see if people had these genetic variations to carry an increased risk of blood clots, heart failure or heart attack.

It was found that a gene that stimulates testosterone in particular JMJD1C gene, thereby doubling the risk of dangerous blood clots in men and increases the risk of heart failure in 7.8 times.

A follow-up validation study involving nearly 172,000 people found that the same gene increased the risk of heart attack by 37 percent.

These findings are consistent with previous studies on the effect of testosterone on heart health, Dr. Richard Becker, Director of the Institute of the University of Cincinnati, Heart, Lung and Vascular Diseases.

“It could be concluded that the results, while not proof of cause and effect, are certainly consistent with some of the concerns that were raised,” Becker said.

Men who carry this genetic mutation in particular should be aware of the health of their heart, he added.

Would “first identify all factors known and modifiable risk, and probably would be as aggressive as I could,” said Becker. These men should exercise regularly, eat well, not smoke and watch their weight, blood pressure and blood sugar, she said.

Further studies are needed to determine if testosterone levels are naturally high cardiac risk factors to be directly added to Becker.

In addition, the study has shown that older men should think twice before turning to testosterone replacement therapy, well-known experts.

Becker said the administration is US Food and Drug. Now, labeling testosterone product requires warning of a possible increased risk of heart attack and stroke.

It is believed that testosterone contributes to hardening of the arteries, said Becker, and people taking large amounts are more likely to form blood clots.

Mintz said that “medical replacement therapy testosterone has declined in recent years, but remains at a significant level. These formulation requirements are based on social pressures and lack of education in this area “.

At the age of men worried about their power often influenced by television and radio spots testosterone supplements to buy counters, Mintz said.

“Testosterone replacement therapy is not attractive, but it’s really dangerous to administer it to patients who have no real medical indication and known proven benefit,” Mintz concluded.